Pediatric Technology Center Request for Proposals

Predictive Decision Support to Prevent CLABSI
Central Line-associated bloodstream infections (CLABSI) not only cause both morbidity and mortality in patients, they also increase healthcare costs with complexity of care and increased length of stay. Children’s Healthcare of Atlanta is a large, tertiary care pediatric healthcare system. Because of volume and subspecialty patients, Children’s cares for a significant number of patients who have central lines. While Children’s employs evidence-based bloodstream infection prevention practices to reduce or eliminate these infections, CLABSI still occur.

Ideally, a more accurate early identification and clinical alerting of CLABSI risk would drive targeted, enhanced prevention practices for patients identified as increased risk. Given the burden to both patients and the healthcare system, even a modest reduction in CLABSI rates would having meaningful and lasting impact.

Proposals from researchers are sought for the following 3 categories:

  1. Data identification, extraction, and harmonization to support CLABSI predictive modeling. This may include use of structured, unstructured, or other data sources. In order to support the project’s second and third phases, transformation of data into the OMOP common data model is preferred. Data should be made available to researchers for the project’s second phase.
  2. Predictive model development to assess individual patient risk for CLABSI at time of admission and then daily throughout hospitalization. Relevant clinical data for model development will be made available in harmonized form using a standardized data format such as OMOP. Expected output will be both model performance characteristics as well as a runnable model that can ingest clinical data in the provided format and return an individualized CLABSI risk prediction.
  3. CLABSI Risk Decision Support application. The clinical decision support application should be able to retrieve patient information from CHOA’s Epic system at point of care, convert those data to the format used for predictive model generation, and display individual patient CLABSI risk to the clinician based on the model developed in phase two. In additional to the technical strategy, describing the requirements gathering, prototyping, and UX design approach is highly encouraged.
Up to $75,000 for each category. A single team may propose for multiple categories. Coordination amongst proposing teams ahead of submission is encouraged by not required.

Proposers should provide anticipated timeframe to conduct the project as well as major milestones in this process. Project should be completed in 12-24 months.

Proposal Due Date: February 2nd, 2018
Anticipated Start Date: March 1st, 2018

For All PTC Seed and Pilot Grants
Program Purpose
To stimulate new research projects, build new collaborations, and increase extramural funding for pediatric research.

All applications must involved two or more investigators, at least one from Georgia Tech and at least one of whom:
  • has a primary faculty appointment in the Emory Department of Pediatrics
  • is on the professional staff at Children's Healthcare of Atlanta (CHOA). This includes those Emory faculty outside of the DEpartment of Pediatrics who are on CHOA medical staff and all non-faculty clinicians who are on CHOA medical staff.
Georgia Tech faculty applicants who have previously received funding from CHOA sources (through the Center for Pediatric Nanomedicine, the Center for Pediatric Innovation, or the Center for Transforming Pediatric Healthcare Delivery) are required to have fulfilled the terms of the prior award (reporting and application for extramural funding) in order to be eligible. Applications are strongly encouraged from faculty who have not previously received CPN, CPI, or CTPHD support.

The principal investigator(s) must:
  • Submit a progress report to the center director within six months of the end date of the pilot project.
  • Submit a related application for extramural funding within one year of the end date of the pilot project.
  • Proposal budgets must include administrative support and data support as needed.
Please contact Erin Kirshtein for guidance prior to submission.

Intellectual Property
Please take a moment to familiarize yourself with the CHOA/GT IP agreement, which covers research funded by this mechanism. An overview of the agreement is appended below.

Submission Links
To: Faculty and Researchers working on Children’s Healthcare of Atlanta Projects
From: Georgia Tech Research Corporation
Re: Intellectual Property Rights under Children’s Healthcare of Atlanta Agreement
Date: January 2014

The Georgia Tech Research Corporation is pleased to announce that Children’s and GTRC entered into a reciprocal Intellectual Property Agreement to address ownership and management of intellectual property. In addition to addressing the management and ownership of intellectual property that both Georgia Tech and Children’s employees are named as inventors, the IP Agreement addresses ownership rights each institution would have when intellectual property is solely created by employees of one party while utilizing funds (whether directly or indirectly) of the other party, other resources provided by the other party, or projects otherwise supported or initiated by the other party. In all cases, GTRC and Children’s jointly own the resulting intellectual property, patent administration decisions will be made jointly by the parties, and any agreements to commercialize the intellectual property will be jointly made. Licensing income will be shared equally between GTRC and Children’s, after distribution of the inventor’s share of any income that is due under the inventor’s institutional IP policy, but before any distributions to the inventor’s college or unit.

For the purpose of the IP agreement, resources can include not only funds provided through a sponsored grant or contract, but any monetary or other financial contribution, whether directly from Children’s or as a subcontract or other ‘pass through’ from a third party, Georgia Tech department, or affiliated Georgia Tech organization. Non-financial contributions such as patient data, facilities, initiated projects, personnel and equipment are considered resources, with respect to the agreement, as well.

If federal funds will also be used in the research, please be aware that federal law prohibits assignment of federally funded intellectual property to a third party. Thus, for any intellectual property funded by the U.S. Government but also using funds or resources of Children’s, to avoid requiring segregation of funds, GTRC will have to request permission from the funding agency for the partial assignment. If the funding agency grants permission, the intellectual property will be handled in accordance with the agreement as outlined above. If permission from the funding agency to assign is denied or delayed for more than five years and no license has been executed at that time, a non-exclusive, royalty free license, with the right to sublicense, to the intellectual property will be granted to Children’s.

If any undergraduate students, visiting scholars, or other non-employee researcher will be working on a project that uses Children’s funds or resources, that non-employee researcher must sign an appropriate agreement assigning their intellectual property to GTRC. Please contact Sherry Farrugia, the Children’s research collaboration coordinator, to ensure that is done prior to commencement of the research.

Also, if a collaboration with a third party is planned for a project in which Children’s funds or resources will be used, GTRC must enter into an agreement with that third party prior to commencement of the collaboration to address the collaborative research and any intellectual property that may be developed. Please contact Sherry Farrugia to initiate such an agreement.

Please contact Sherry Farrugia ( with any questions.